Saturday, 12 March 2016

Is It Gluten or FODMAP's Which Causes Self-Diagnosed Non-Celiac Gluten Sensitivity?

Gluten sensitive individuals cannot tolerate gluten and may develop gastrointestinal symptoms similar to those in celiac disease, but the overall clinical picture is typically less severe. Non-celiac gluten sensitivity refers to an adverse reaction to eating gluten that usually does not lead to damage of the small intestine.

Non-celiac gluten sensitivity was virtually unrecognized a decade ago but is now a perplexing problem that has driven many studies in the past few years. Its prevalence appears to be more wide spread than celiac disease itself.  It was a topic of hot debate at the International Celiac Disease Symposium in late 2013, where it was widely debated if the frequency of gluten sensitivity is really due to gluten, or whether other factors and food culprits could be part of the cause.

For people with self-diagnosed non-celiac gluten sensitivity, it may not be gluten which is causing their problem. An Australian researcher into gluten sensitivity, Peter Gibson, of Melbourne's Monash University believes that people who get relief with a gluten free diet, do so because they avoid FODMAPs rather than gluten itself. ''What our study has shown is that, in people with gut symptoms who have had some relief with the gluten free diet, it is not the gluten that is the culprit, but it is more likely to be FODMAPs,'' Gibson says. 

FODMAP’s stands for Fermentable, Oligosaccharides, Disaccharides, Monosaccharides And Polyols. They are all short-chain carbohydrates found in many foods, particularly in the western diet,  which can be poorly absorbed by some peopleThey are in particularly high amounts in wheat, rye and barley, the three cereals that contain gluten. So researchers are curious whether the benefits of the gluten-free diet among people with gluten sensitivity may actually be a result of reducing FODMAP intake.
Examples of oligosaccharides include fructans (polymers of fructose); disaccharides include lactose; monosaccharides include fructose; and polyols include sugar alcohols such as sorbitol and mannitol.

Poor absorption of most FODMAP carbohydrates is common to everyone. Any FODMAPs that are not absorbed in the small intestine pass into the large intestine large where bacteria normally found in the gut ferment them. The resultant production of gas potentially results in bloating and flatulence. Most individuals do not suffer significant symptoms but some may suffer the symptoms of IBS. Restriction of FODMAP intake in IBS sufferers has been found to result in improvement of symptoms.

As for people mistakenly believing they are gluten sensitive, Gibson suggested that there were two other possible explanations, other than gluten sensitivity itself which could be making them feel better on a gluten free diet:

1.   People felt better for avoiding wheat and gluten products because of their high percentage of FODMAPs. He suggests that FODMAPs might be the factor leading to the symptoms such as bloating and gut distress, rather than gluten itself. Gibson says, 'Why gluten has been blamed is that people do often improve with a gluten free diet because wheat, rye and barley, the three cereals that contain gluten, all have high amounts of FODMAPs in them.” 

2.   Gibson also believes people may report improvements on a gluten free diet because it makes them quite literally ''feel better'', even if their gastro-intestinal symptoms do not improve. Current evidence suggests that many patients with self-reported non-coeliac gluten sensitivity continue to experience gastrointestinal symptoms on a gluten free diet but continue to restrict gluten as they report 'feeling better'. Gibson suggests that 'It may be that people with gut symptoms feel better on the gluten-free diet because they are less depressed.


However, when considering the involvement of FODMAPs in non-celiac gluten sensitivity, it is important to remember that FODMAPs are found in a variety of other foods as well, like onions, broccoli, beans, apples and milk.  All of these foods can be difficult for some people to digest and cause gastrointestinal symptoms as well, but do people with non-celiac gluten sensitivity react to these products as well?
Recent research has revealed that gluten or wheat sensitivity occurs in approximately 30% of people with IBS (Irritable Bowel Syndrome), a prevalence rate that is much higher than in the general population. So should IBS be included as part of the spectrum of gluten sensitivity disorders? While some people with IBS may benefit from a gluten free diet it isn’t the solution for all people with IBS, and there are other factors to uncover.
Dietitian Susan Shepherd developed the low FODMAP diet in 1999 as a treatment for IBS, and over the last several years it has gained significant attention among both patients and researchers for effectiveness. A study published in June 2013 found that, in some people with gluten sensitivity and IBS, reducing the intake of FODMAPs alleviated symptoms better than a gluten free diet. However, other studies found that people with IBS and gluten sensitivity reported improved symptoms on a gluten free diet, and the benefits remained even when high FODMAP foods like beans were reintroduced.
What these studies on IBS and FODMAPs demonstrate is that what works for one person may not work for another, and each person needs to have an individualized dietary plan that suits them. Whether the symptoms are caused by gluten or by FODMAPs the important thing for the sufferer is know which foods affect them and to avoid those foods.
From my personal experience with my own family that makes sense. Peppermint makes me sneeze, capsicum makes me vomit, my eldest daughter has sub-acute lupus so has to avoid any viral infections, my second daughter is allergic to nickel and cannot eat seafood, my third daughter has celiac disease so of cause cannot eat gluten and my son has a skin reaction to the sun. So we are all of the same DNA but all have our peculiarities as far as allergies etc. are concerned.  We just cater for everyone’s needs and it is not a problem at all.

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